pentobarbital will reduce the level or influence of midostaurin by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Sturdy CYP3A4 inducers may well lessen midostaurin concentrations leading to lowered efficacy.pentobarbital raises effects of ifosfamide by affecting hepatic enzyme CYP2B6 metabolism. Use